Endocrine Abstracts

Introduction: Langerhan Cells Histiocytosis (LCH) is a rare heterogeneous idiopathic clinical entity involving clonal proliferation of Langerhan cells that may infiltrate most commonly bone, skin, lymph nodes or lungs. It affects mainly children between 5 and 15 years. The most common endocrine manifestation is diabetes insipida.Clinical case: The authors describe a case of a 19-year-old female patient, admitted in the Transition Follow-up of the Endocri...

Introduction: Insulin autoimmune syndrome or Hirata disease is a rare cause of hypoglycemia without prior insulin exposure. Approximately 400 cases were reported, mostly in Japan. It’s associated with other autoimmune diseases or exposure to sulfhydryl-containing drugs.Case report: A 56-year-old Caucasian woman presented with a 20-month history of hypoglycemia ameliorated by sugar intake. She had a past history of autoimmune thyroiditis, asthma and ...

Introduction: Diabetes mellitus (DM) is one of the main causes of end-stage renal disease (ESRD). Renal transplantation is the most effective form or renal replacement.Methods: Retrospective, descriptive study of a sample of 108 diabetic patients admitted as candidates to renal transplant from January 1991 to December 2011, using the SPSS programme, version 20.0.Results: 11 women and 97 men were evaluated (medium age: 58±8.2 y...

Introduction: The TNM staging system for well differentiated thyroid cancer (WDTC) considers tumours over 4 cm diameter limited to the thyroid or tumours with minimal extra-thyroid extension to be classified as pT3. This stage can be considered quite heterogeneous, as different clinical and pathologic characteristics seem to have distinct prognosis value.Aims: To determine prognostic factors amongst clinical, laboratorial, histologic and radiologic chara...

Introduction: Malignant pheocromocytomas are rare. Metastatic disease may be present at the time of diagnosis or may only be evident after. Prognosis is poor. Currently there is no effective cure.Case report: We describe the case of a 66-year-old woman with a history of pheocromocytoma submitted to left adrenalectomy in 1992. In the past 10 years, she complained of episodes of dorsal back pain associated with hypertensive peaks and tachycardia. In 4/2010...

Introduction: About 20% of fine needle aspiration biopsy of thyroid (FNA) with result of follicular tumour (FT) is malignant. Several factors have been suggested as indicators of malignancy.Objectives: To determine predictive factors of malignancy in FNA with result of FT.Methods: We evaluated retrospectively 140 clinical files of patients with cytology (ultrasound-guided or palpation) of FT. Presence of relationship between malign...

Introduction: The benefits of intensive management of type 1 and type 2 diabetes have been well established in several studies, as DCCT and UKPDS, and include reduced of long term complications. Current guidelines target of A1c<7% is also to achieve in diabetic patient with kidney transplant. Methods to improve patient’s ability to achieve this goal are being explored. Continuous monitoring of glucose in interstitial fluid allows the identification of glycemic excursi...

Introduction: Gestational diabetes (DG) is associated with higher risk of diabetes mellitus (DM), and it’s recommended to perform an oral glucose tolerance test (OGTT) with 75 g after delivery to its reclassification. However, not all scientific societies recommend it.Aim: To evaluate glucose tolerance with OGTT after delivery in women with DG and the risk factors to glucose intolerance in glycaemia at 120′.Methods: Retr...

Introduction: Type 1 Diabetes (DM1) is associated with a destructive autoimmune process of pancreatic b-cells. The presence of anti-islet cells (ICA) antibodies (Ab), as well as for distinctive antigens – GAD65, IA2 or Insulin (IAA) - is related to the disease development.Aim: To evaluate the effect of DM1 antibodies on the measures of glycemic variability (GV) obtain through continuous glucose monitoring (CGM).Materials and m...

Introduction: Pituitary apoplexy (PA) is an endocrine emergency and usually presents with sudden headache and visual fields changes. Pituitary function assessment should be performed promptly and repeated throughout follow-up, regardless of the choice of treatment.Methods/design: Retrospective analysis of patients diagnosed with PA admitted to an Endocrinoloy Department of a tertiary hospital between 2002 and 2017. Review of patients’ medical record...